Volume 7, Issue 2
A Stochastic Immunotherapy Model for Breast Cancer with Pulsed Chemotherapy

Weipeng Zhang, Shiyu Zhang & Hang Wang

J. Nonl. Mod. Anal., 7 (2025), pp. 463-492.

Published online: 2025-04

[An open-access article; the PDF is free to any online user.]

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  • Abstract

In this paper, we consider an immunotherapy model for breast cancer with stochastic perturbations and pulsed chemotherapy. By using stochastic Lyapunov analysis and the strong law of large numbers, we first prove the existence, uniqueness and the stochastic ultimate boundedness of the global positive solution for the model. Then we obtain sufficient conditions for the extinction of tumor cells and the persistence of all three kinds of cells for this model. Finally, we use numerical simulations to verify the theoretical results which are obtained in the paper.

  • AMS Subject Headings

60H10, 65C20

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COPYRIGHT: © Global Science Press

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@Article{JNMA-7-463, author = {Zhang , WeipengZhang , Shiyu and Wang , Hang}, title = {A Stochastic Immunotherapy Model for Breast Cancer with Pulsed Chemotherapy}, journal = {Journal of Nonlinear Modeling and Analysis}, year = {2025}, volume = {7}, number = {2}, pages = {463--492}, abstract = {

In this paper, we consider an immunotherapy model for breast cancer with stochastic perturbations and pulsed chemotherapy. By using stochastic Lyapunov analysis and the strong law of large numbers, we first prove the existence, uniqueness and the stochastic ultimate boundedness of the global positive solution for the model. Then we obtain sufficient conditions for the extinction of tumor cells and the persistence of all three kinds of cells for this model. Finally, we use numerical simulations to verify the theoretical results which are obtained in the paper.

}, issn = {2562-2862}, doi = {https://doi.org/10.12150/jnma.2025.463}, url = {http://global-sci.org/intro/article_detail/jnma/23985.html} }
TY - JOUR T1 - A Stochastic Immunotherapy Model for Breast Cancer with Pulsed Chemotherapy AU - Zhang , Weipeng AU - Zhang , Shiyu AU - Wang , Hang JO - Journal of Nonlinear Modeling and Analysis VL - 2 SP - 463 EP - 492 PY - 2025 DA - 2025/04 SN - 7 DO - http://doi.org/10.12150/jnma.2025.463 UR - https://global-sci.org/intro/article_detail/jnma/23985.html KW - Breast cancer, persistence, extinction, white noise, impulsive effect. AB -

In this paper, we consider an immunotherapy model for breast cancer with stochastic perturbations and pulsed chemotherapy. By using stochastic Lyapunov analysis and the strong law of large numbers, we first prove the existence, uniqueness and the stochastic ultimate boundedness of the global positive solution for the model. Then we obtain sufficient conditions for the extinction of tumor cells and the persistence of all three kinds of cells for this model. Finally, we use numerical simulations to verify the theoretical results which are obtained in the paper.

Zhang , WeipengZhang , Shiyu and Wang , Hang. (2025). A Stochastic Immunotherapy Model for Breast Cancer with Pulsed Chemotherapy. Journal of Nonlinear Modeling and Analysis. 7 (2). 463-492. doi:10.12150/jnma.2025.463
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